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Phase 2 randomized placebo controlled double blind study to assess the efficacy and safety of tecfidera in patients with amyotrophic lateral sclerosis (TEALS Study): Study protocol clinical trial (SPIRIT Compliant)

It has since been studied extensively as a model copper-carrier peptide, and is investigated for its role in skin and extracellular-matrix research, including work on collagen-related gene expression and fibroblast behaviour in cultured models

Right panel: n = 4 (Pfa1), n = 3, p = 0.0014 (Tam)

Every mouse study showed longer life. Some models reported lifespan changes

But the reality is far more nuanced, touching on everything from gastrointestinal physiology to the molecular stability of the peptide itself